Correlation of Malaria Immunity with Expansion of Adaptive-Like Functional CD56-Negative NK Cells





Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria




The expansion of adaptive-like NK cells functioning as a response to malaria infections has been the subject of much research in recent years. A new study published in the journal PLOS Pathogens has found that this expansion is correlated with clinical immunity to malaria and may be an important tool in the fight against the disease.

The study examined the phenotype and function of NK cells from patients with acute malaria and those with a history of malaria infection. It was found that the NK cells from the malaria-infected group showed increased expression of several molecules associated with adaptive-like functions, such as CD56, interleukin-2 receptor gamma chain (IL2Rγ), and killer cell immunoglobulin-like receptors (KIRs). Furthermore, these NK cells also had enhanced cytolytic activity, which is similar to that of NK cells that have been activated by T cells.

The study also observed that the expansion of NK cells with adaptive-like functions was associated with clinical immunity to malaria. This is significant, as it suggests that NK cells may play a role in the body’s ability to control the infection.

Overall, the findings of this study suggest that the expansion of adaptive-like functional CD56-negative NK cells may be an important factor in the host’s ability to combat malaria infection. Further research is needed to better understand how NK cells interact with other immune cells to provide protection from the disease. This knowledge could be used to develop strategies to enhance the body’s natural responses to the infection and, ultimately, improve outcomes for those affected by malaria.