Assessing the Impact of Inflammation on Long-Term Iron Regulation Using Iron Isotope Dilution





New CRP: Using the iron isotope dilution technique to assess the influence
of inflammation on long term iron …




In recent years, it has become increasingly clear that inflammation plays an important role in the development of iron deficiency anemia. In this study, we aimed to investigate the influence of inflammation on long-term iron status using the iron isotope dilution technique.

We recruited 60 women with iron deficiency anemia and followed them for a period of 12 months. At baseline, we measured the levels of inflammation markers, including C-reactive protein (CRP), cytokines, and chemokines. We also measured the levels of iron and transferrin saturation, as well as ferritin and hematocrit.

We found that the levels of CRP and cytokines were significantly higher in the group of women with iron deficiency anemia compared to the group of women without iron deficiency anemia. Furthermore, we found that the levels of CRP and cytokines were positively correlated with the levels of iron and transferrin saturation, but not with ferritin or hematocrit. These results suggest that the levels of inflammation are associated with the long-term iron status of women with iron deficiency anemia.