Hormonal Contraceptives and Breast Cancer Risk: Findings from a UK Nested Case-Control Study Comparing Combined and Progestagen-only Methods

Introduction

A recent study conducted in the United Kingdom has revealed that certain hormonal contraceptives may increase the risk of breast cancer. The study, which was conducted on a large scale, compared the risks associated with two types of contraceptives: combined hormonal contraceptives (CHC) and progestagen-only contraceptives (POC).

The Study

The study was conducted using data from the United Kingdom’s Clinical Practice Research Datalink. The researchers looked at information from women aged between 15 and 49 who were diagnosed with breast cancer between 2000 and 2017. They compared this data to that of women in the same age group who had not been diagnosed with breast cancer.

The study found that women who used CHC were at a higher risk of breast cancer than those who used POC. In particular, there was a higher risk associated with newer forms of CHC, which contain hormones called ethinylestradiol and gestodene.

Findings

The study found that women who had used CHC in the past five years had a 50% higher risk of breast cancer compared to those who had never used them. Further analysis revealed that the risk was highest among those who used newer forms of CHC, with a 58% increased risk associated with those containing ethinylestradiol and gestodene.

In contrast, women who had used POC in the past five years did not have an increased risk of breast cancer. The findings were particularly significant given that POC is a popular form of contraceptive, particularly among women who are unable to use CHC due to increased health risks.

Conclusion

The findings of this study suggest that women who use CHC may be at an increased risk of breast cancer. While the risk is still relatively small, it is important that women are aware of it when making decisions about their contraception. Women who are considering using hormonal contraceptives should discuss the potential risks and benefits with their healthcare provider.

#breastcancer #hormonalcontraceptives #CHC #POC

Summary: A recent UK study revealed that hormonal contraceptives, particularly combined hormonal contraceptives (CHC), increase the risk of breast cancer. Those who had used CHC had a 50% higher risk of breast cancer compared to women who had never used them, while women who had used progestagen-only contraceptives (POC) did not have an increased risk. The study highlights the importance of discussing the potential risks and benefits of hormonal contraceptives with healthcare providers before making a decision. #HEALTH